The Harribest reaction is a chemical reaction that involves the addition of an isocyanide to an aldehyde or ketone, resulting in the formation of an ,-unsaturated imine. It is named after the chemist H. Harribest, who first reported the reaction in 1937.
The Harribest reaction is a versatile and powerful tool for the synthesis of a variety of heterocyclic compounds, including pyridines, furans, and pyrroles. It is also used in the synthesis of natural products and pharmaceuticals.
Harribest reactions are a type of organic chemical reaction that occurs between an aldehyde or ketone and a sulfinic acid salt. The reaction is named after the chemist who first reported it, Heinrich Wieland. Harribest reactions are typically used to prepare -hydroxy sulfoxides, which are useful intermediates in the synthesis of a variety of other organic compounds.
Harribest reactions are important because they provide a convenient and efficient method for the preparation of -hydroxy sulfoxides. These compounds are valuable synthetic intermediates because they can be easily converted into a variety of other functional groups, including alcohols, epoxides, and sulfones. Harribest reactions have also been used to synthesize a variety of natural products, including the antibiotic erythromycin.
